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1. Two types of mucoid (basophil) cell, described as R and S, can be distinguished in the human adenohypophysis by a performic acid-Alcian blue method for cystine.

2. The relationship of the S—R terminology to other nomenclatures of human pituitary basophils is discussed.

3. The R cell, which contains little cystine, is the common mucoid cell of the human adenohypophysis: it is the cell which undergoes hyalinization in Cushing's syndrome and after cortisone therapy.

4. The S cell is found in the normal pituitary and, in great numbers, in Addison's disease and in shock: it is suggested that this cell is responsible for corticotrophin-synthesis.

This article has been cited by other articles:

				M. S. BRUNO, W. B. OBER, H. S. KUPPERMAN, and J. A. EPSTEIN Coexistent Addison's Disease and Thyrotoxicosis Arch Intern Med, August 1, 1962; 110(2): 155 - 161. [Abstract] [PDF]