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Journal of Endocrinology (2002) 172, R1-R5       DOI: 10.1677/joe.0.172R001
© 2002 Society for Endocrinology
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Journal of Endocrinology, Vol 172, Issue 1, R1-R5
Copyright © 2002 by Society for Endocrinology

Articles

Glucocorticoid-induced glucose release is abolished in trout hepatocytes with elevated hsp70 content

AN Boone, B Ducouret, and MM Vijayan


The metabolic potential of cells with elevated heat shock protein 70 (hsp70) content was examined by measuring unstimulated and glucocorticoid-stimulated glucose release in trout hepatocytes maintained in primary culture. Exposure of hepatocytes to either heat shock (HS;+15 degrees C) or sodium arsenite (50 microM) did not affect cell viability, but resulted in significantly higher hsp70 levels over a 24 h recovery period. Hsp70 accumulation had no significant impact on unstimulated glucose release, but completely abolished cortisol-induced glucose release in trout hepatocytes. This lack of glucocorticoid responsiveness corresponded with lower glucocorticoid receptor protein levels. Together, our results suggest that stressor-induced hsp70 accumulation, while important for maintaining cellular homeostasis, may impair metabolic adjustments to subsequent stressors in animals, especially those that are glucocorticoid-dependent.


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