HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McSWINEY, R. R. Articles by PRUNTY, F. T. G. Search for Related Content PubMed PubMed Citation Articles by McSWINEY, R. R. Articles by PRUNTY, F. T. G.

1. The protein anabolic properties of three derivatives of testosterone have been investigated.

2. 17-methyl-⁵-androstene-3β: 17β-diol and 17-methyl androstane-3: 17β-diol produced nitrogen retention in doses approaching those reported as androgenic by other investigators.

3. The third compound, 17-ethyl-19-nortestosterone (17-ENT), which was studied in greatest detail, produced nitrogen retention in moderate dosage. Other metabolic effects were a fall in urinary calcium and, usually, a fall in faecal calcium. Phosphorus balance agreed with that calculated from nitrogen and calcium balance. Plasma calcium showed no consistent variation, while plasma phosphorus fell. 17-ENT also brought about marked changes in weight, and in fluid, sodium, potassium and chloride balances which are probably due partly to the retention of nitrogen and corresponding intracellular fluid, and partly to increased sweating. When given to two patients with osteoporosis due to prolonged steroid therapy, and receiving prednisone, the compound appeared to aid the restoration of a positive calcium balance. 17-ENT was found to have definite androgenic effects, but their intensity requires further study.

This article has been cited by other articles:

				H. G. Greene, H. Blumberg, and W. Metcalf Some Quantitative Aspects of Nitrogen Retention with Norethandrolone: The Ratio of Experimental Excretion to Control Excretion JAMA, January 12, 1963; 183(2): 108 - 110. [Abstract] [PDF]