JOE Tips for Better Browsing
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pearce, S.
Right arrow Articles by Thakker, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Pearce, S.
Right arrow Articles by Thakker, R.
Journal of Endocrinology, Vol 154, Issue 3, 371-378
Copyright © 1997 by Society for Endocrinology

Articles

The calcium-sensing receptor: insights into extracellular calcium homeostasis in health and disease

SH Pearce and RV Thakker


The cloning of the BoPCaR1 gene has helped to elucidate many aspects of normal extracellular calcium homeostasis, particularly as applied to the regulation of PTH secretion, calcitonin secretion and renal calcium reabsorption. In addition, loss and gain of function mutations have been found to cause the clinical syndromes of FBH, NSHPT and ADHH respectively. The CaR has also been implicated in the mechanisms leading to primary and uraemic hyperparathyroidism, and autoimmune parathyroid destruction. The recent demonstration that the CaR regulates non-selective cation channel function in rat hippocampal neurones suggests that it may also have a role within the central nervous system that is entirely unrelated to calcium homeostasis (Ye et al. 1996). Finally, the prospect of CaR agonists and antagonists, which may allow PTH secretion to be regulated independently of the serum calcium concentration, also holds much promise for the medical treatment of hyperparathyroidism, renal osteodystrophy and osteoporosis.


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
A. Richter, M. K. Kuhlmann, E. Seibert, P. Kotanko, N. W. Levin, and G. J. Handelman
Vitamin C deficiency and secondary hyperparathyroidism in chronic haemodialysis patients
Nephrol. Dial. Transplant., June 1, 2008; 23(6): 2058 - 2063.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. Marz, U. Seelhorst, B. Wellnitz, B. Tiran, B. Obermayer-Pietsch, W. Renner, B. O. Boehm, E. Ritz, and M. M. Hoffmann
Alanine to Serine Polymorphism at Position 986 of the Calcium-Sensing Receptor Associated with Coronary Heart Disease, Myocardial Infarction, All-Cause, and Cardiovascular Mortality
J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2363 - 2369.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Huang, J.-i. Niwa, G. Sobue, and G. E. Breitwieser
Calcium-sensing Receptor Ubiquitination and Degradation Mediated by the E3 Ubiquitin Ligase Dorfin
J. Biol. Chem., April 28, 2006; 281(17): 11610 - 11617.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Purroy and N. K. Spurr
Molecular genetics of calcium sensing in bone cells
Hum. Mol. Genet., October 1, 2002; 11(20): 2377 - 2384.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. J. Pace, L. Gama, and G. E. Breitwieser
Dimerization of the Calcium-sensing Receptor Occurs within the Extracellular Domain and Is Eliminated by Cys {right-arrow} Ser Mutations at Cys101 and Cys236
J. Biol. Chem., April 23, 1999; 274(17): 11629 - 11634.
[Abstract] [Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Society for Endocrinology.