HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Pavia, M A Articles by Zaninovich, A A Search for Related Content PubMed PubMed Citation Articles by Pavia, M A, Jr Articles by Zaninovich, A A

The effect of in vivo administration of cadmium chloride on the pituitary-thyroidal axis was assessed in 200 g body weight Wistar rats. A dose of 2·5 mg/kg body weight was injected i.v. 24 h before the experiments were initiated. Plasma thyroxine (T₄) and tri-iodothyronine (T₃) concentrations in cadmium-treated rats were significantly (P<0·01) decreased, whereas plasma TSH failed to increase in response to low T₄ and T₃. However, the TSH response to TRH and the pituitary content of TSH in these rats were both normal. Cadmium induced a significant (P<0·01) decrease in 4-h thyroidal ¹³¹I uptake and in thyroid/plasma radioactivity ratio. The in vitro conversion of T₄ to T₃ in the pituitary was significantly (P<0·01) blocked by cadmium whereas there was no in vivo effect. Parameters of peripheral T₄ kinetics in cadmium-treated rats, such as metabolic clearance rate (P<0·01), fractional turnover rate (P<0·01), absolute disposal rate (P<0·05), urinary clearance (P<0·05) and faecal clearance (P<0·05), were all decreased by cadmium. The lack of response of TSH to low plasma T₄ and T₃ and the normal response to exogenous TRH in this and in other non-thyroidal illness syndromes produced by other pathologies suggest a decreased stimulation of pituitary thyrotrophs by endogenous TRH.

Journal of Endocrinology (1997) 154, 113–117

This article has been cited by other articles:

				J. G. Schnitzler, U. Siebert, P. D. Jepson, A. Beineke, T. Jauniaux, J.-M. Bouquegneau, and K. Das HARBOR PORPOISE THYROIDS: HISTOLOGIC INVESTIGATIONS AND POTENTIAL INTERACTIONS WITH ENVIRONMENTAL FACTORS J. Wildl. Dis., October 1, 2008; 44(4): 888 - 901. [Abstract] [Full Text] [PDF]