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Introduction: Since Ymer & Herington (1985) refocused attention on the serum growth hormone (GH) binding protein (GHBP), it has attracted considerable research effort. Despite this, much remains to be resolved regarding its physiological function(s) and its regulation (which provides clues to function). The presence of a high affinity GHBP has significant implications for understanding the growth process, for understanding maternal control of foetal development and for attempts to enhance growth using genetically engineered GH analogues. To date, these implications have not been adequately explored.

Although there is evidence for a low affinity high capacity GHBP (Baumann & Shaw 1990), the present review will focus on the high affinity GHBP. It will summarize what is known regarding distribution, regulation and suggested roles of the high affinity GHBP. Evidence that GHBP has a significant role in the endocrinology of pregnancy and control of foetal growth will be discussed. Since progress in GHBP

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