JOE Society for Endocrinology Archive
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Endocrinology (1996) 150, 1-7       DOI: 10.1677/joe.0.1500001
© 1996 Society for Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (46)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schaller, M D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schaller, M D

The focal adhesion kinase

 M D Schaller

The focal adhesion kinase, FAK or pp125FAK, is a 125 kDa protein tyrosine kinase (PTK), whose name is derived from its subcellular localization (Schaller et al. 1992). Although originally identified as a putative substrate for pp60v-src (Kanner et al. 1990), an oncogenic PTK, FAK has gained its notoriety as an element of a signaling pathway regulated by cell surface receptors called integrins (Schaller & Parsons 1993, 1994). Integrins are heterodimeric, transmembrane proteins that can simultaneously bind to proteins of the extracellular matrix (ECM), e.g. fibronectin, and to components of the actin cytoskeleton, e.g. talin and {alpha}-actinin (Burridge et al. 1988, Turner & Burridge 1991). In addition to their role in cell adhesion to ECM and in anchoring the cytoskeleton, the integrins can transduce extracellular cues into cytoplasmic signals (Damsky & Werb 1992, Hynes 1992, Schwartz 1992, Juliano & Haskill 1993), which include the tyrosine phosphorylation and enzymatic activation of FAK




This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
K. Sakurama, K. Noma, M. Takaoka, Y. Tomono, N. Watanabe, S. Hatakeyama, O. Ohmori, S. Hirota, T. Motoki, Y. Shirakawa, et al.
Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
Mol. Cancer Ther., January 1, 2009; 8(1): 127 - 134.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Watanabe, M. Takaoka, K. Sakurama, Y. Tomono, S. Hatakeyama, O. Ohmori, T. Motoki, Y. Shirakawa, T. Yamatsuji, M. Haisa, et al.
Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo
Clin. Cancer Res., July 15, 2008; 14(14): 4631 - 4639.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Onofri, M. Messa, V. Matafora, G. Bonanno, A. Corradi, A. Bachi, F. Valtorta, and F. Benfenati
Synapsin Phosphorylation by Src Tyrosine Kinase Enhances Src Activity in Synaptic Vesicles
J. Biol. Chem., May 25, 2007; 282(21): 15754 - 15767.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Halder, A. A. Kamat, C. N. Landen Jr., L. Y. Han, S. K. Lutgendorf, Y. G. Lin, W. M. Merritt, N. B. Jennings, A. Chavez-Reyes, R. L. Coleman, et al.
Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy.
Clin. Cancer Res., August 15, 2006; 12(16): 4916 - 4924.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. A. Garces, E. V. Kurenova, V. M. Golubovskaya, and W. G. Cance
Vascular Endothelial Growth Factor Receptor-3 and Focal Adhesion Kinase Bind and Suppress Apoptosis in Breast Cancer Cells
Cancer Res., February 1, 2006; 66(3): 1446 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. KUMAR, R. MURPHY, P. ROBINSON, L. WEI, and A. M. BORIEK
Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-{kappa}B transcription factor
FASEB J, October 1, 2004; 18(13): 1524 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. K. Sood, J. E. Coffin, G. B. Schneider, M. S. Fletcher, B. R. DeYoung, L. M. Gruman, D. M. Gershenson, M. D. Schaller, and M. J.C. Hendrix
Biological Significance of Focal Adhesion Kinase in Ovarian Cancer: Role in Migration and Invasion
Am. J. Pathol., October 1, 2004; 165(4): 1087 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Lim, I. Han, J. Jeon, H. Park, Y.-Y. Bahk, and E.-S. Oh
Phosphorylation of Focal Adhesion Kinase at Tyrosine 861 Is Crucial for Ras Transformation of Fibroblasts
J. Biol. Chem., July 9, 2004; 279(28): 29060 - 29065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. J. Sundberg, L. M. Galante, H. M. Bill, C. P. Mack, and J. M. Taylor
An Endogenous Inhibitor of Focal Adhesion Kinase Blocks Rac1/JNK but Not Ras/ERK-dependent Signaling in Vascular Smooth Muscle Cells
J. Biol. Chem., August 8, 2003; 278(32): 29783 - 29791.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
V. M. Golubovskaya, S. Gross, A. S. Kaur, R. I. Wilson, L.-H. Xu, X. H. Yang, and W. G. Cance
Simultaneous Inhibition of Focal Adhesion Kinase and Src Enhances Detachment and Apoptosis in Colon Cancer Cell Lines
Mol. Cancer Res., August 1, 2003; 1(10): 755 - 764.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Dunty and M. D. Schaller
The N Termini of Focal Adhesion Kinase Family Members Regulate Substrate Phosphorylation, Localization, and Cell Morphology
J. Biol. Chem., November 15, 2002; 277(47): 45644 - 45654.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. J. Bruce-Staskal, C. L. Weidow, J. J. Gibson, and A. H. Bouton
Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake
J. Cell Sci., January 7, 2002; 115(13): 2689 - 2700.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. G. Cance, J. E. Harris, M. V. Iacocca, E. Roche, X. Yang, J. Chang, S. Simkins, and L. Xu
Immunohistochemical Analyses of Focal Adhesion Kinase Expression in Benign and Malignant Human Breast and Colon Tissues: Correlation with Preinvasive and Invasive Phenotypes
Clin. Cancer Res., June 1, 2000; 6(6): 2417 - 2423.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
F. Anfosso, N. Bardin, V. Frances, E. Vivier, L. Camoin-Jau, J. Sampol, and F. Dignat-George
Activation of Human Endothelial Cells via S-Endo-1 Antigen (CD146) Stimulates the Tyrosine Phosphorylation of Focal Adhesion Kinase p125FAK
J. Biol. Chem., October 9, 1998; 273(41): 26852 - 26856.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. L. Ostergaard, O. Lou, C. W. Arendt, and N. N. Berg
Paxillin Phosphorylation and Association with Lck and Pyk2 in Anti-CD3- or Anti-CD45-stimulated T Cells
J. Biol. Chem., March 6, 1998; 273(10): 5692 - 5696.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Burgaya, M. Toutant, J.-M. Studler, A. Costa, M. Le Bert, M. Gelman, and J.-A. Girault
Alternatively Spliced Focal Adhesion Kinase in Rat Brain with Increased Autophosphorylation Activity
J. Biol. Chem., November 7, 1997; 272(45): 28720 - 28725.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Wong, S. Uddin, B. Majchrzak, T. Huynh, A. E. I. Proudfoot, L. C. Platanias, and E. N. Fish
RANTES Activates Jak2 and Jak3 to Regulate Engagement of Multiple Signaling Pathways in T Cells
J. Biol. Chem., March 30, 2001; 276(14): 11427 - 11431.
[Abstract] [Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the Society for Endocrinology.