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Journal of Endocrinology (1957) 15, 307-309       DOI: 10.1677/joe.0.0150307
© 1957 Society for Endocrinology
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THE METABOLIC REDUCTION OF 16{alpha}-HYDROXY-OESTRONE TO OESTRIOL IN MAN

 J. B. BROWN and G. F. MARRIAN

16{alpha}-Hydroxyoestrone was administered by intramuscular injection in propylene glycol solution to a normal man and to a postmenopausal woman. In the two experiments 44 and 33% respectively of the administered substance was subsequently excreted in the urine as oestriol. No evidence indicative of the metabolic conversion of 16{alpha}-hydroxyoestrone to oestrone or oestradiol-17β was obtained.






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Copyright © 1957 by the Society for Endocrinology.