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Journal of Endocrinology (1996) 149, 7-12       DOI: 10.1677/joe.0.1490007
© 1996 Society for Endocrinology
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Age-related endocrine deficiencies and fractures of the proximal femur. I Implications of growth hormone deficiency in the elderly

S Boonen, J Aerssens and J Dequeker

Introduction: Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture (Peck et al. 1993). Type I (postmenopausal) osteoporosis is characterized by a disproportionate postmenopausal trabecular bone loss in a subset of women and complicated by vertebral compression fractures. Type II (senile) osteoporosis, on the other hand, is associated with a proportionate age-related loss of both cortical and trabecular bone, in men as well as in women, ultimately leading to hip fractures (Riggs & Melton 1983). Fractures of the proximal femur in the elderly represent a global issue, associated with significant morbidity and mortality (Cummings et al. 1985, Maggi et al. 1991, Mander & Lindahl 1993, Melton 1993). The cumulative incidence of hip fractures reaches 33% in women and 17% in men by 90 years of age (Melton et al. 1992). However




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