HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Geisler, J Articles by Lønning, P E Search for Related Content PubMed PubMed Citation Articles by Geisler, J Articles by Lønning, P E

Plasma levels of oestradiol (Oe₂), oestrone (Oe₁), oestrone sulphate (Oe₁S), androstenedione, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), sex hormone-binding globulin (SHBG) and the gonadotrophins (FSH and LH) were determined in 20 postmenopausal women with breast cancer treated with the anti-oestrogen droloxifene (3-hydroxytamoxifen). Plasma oestrogens were measured before and after 3, 6 and 12 months of therapy. The other hormones were measured before and after 6 months of therapy. Droloxifene treatment had no significant influence on plasma levels of Oe₂. Plasma levels of Oe₁ and Oe₁S increased during treatment (mean increase of 11·9-15·9% and 24·5–69·4% respectively after different time-intervals on treatment). The Oe₁S/Oe₁ and Oe₁S/Oe₂ ratios increased by mean values of 13·8–45·2% and 25·9–52·4% respectively. Plasma SHBG increased significantly by a mean value of 73·9%, while FSH and LH fell non-significantly by 19·7% and 20·4% respectively. Plasma levels of testosterone, androstenedione, DHEA and DHEAS all increased during treatment, but none of these alterations were of statistical significance. While the influence of droloxifene on plasma SHBG resembled that which is seen during treatment with tamoxifen, its influence on plasma oestrogens and the gonadotrophins seems to be different. Possible explanations of such differences and the clinical implications of alterations in plasma hormones during treatment with droloxifene are discussed.

Journal of Endocrinology (1995) 146, 359–363

This article has been cited by other articles:

				D. M. Herrington, B. E. Pusser, W. A. Riley, T. Y. Thuren, K. B. Brosnihan, E. A. Brinton, and D. B. MacLean Cardiovascular Effects of Droloxifene, a New Selective Estrogen Receptor Modulator, in Healthy Postmenopausal Women Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1606 - 1612. [Abstract] [Full Text] [PDF]