HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vieira, A V Articles by Vieira, P M Search for Related Content PubMed PubMed Citation Articles by Vieira, A V Articles by Vieira, P M

The retinoids comprise a family of polyisoprenoid lipids that includes vitamin A (retinol) and structurally related compounds. The biological activity of retinoids can be modified, for example, by changes in the molecules' state of oxidation and cis/trans isomerization. Their activity is also dependent on the levels of specific types of retinoid-binding proteins which exist in extracellular, cytosolic and nuclear compartments. The role of retinoids in gene expression represents an important biological function for this family of molecules. Retinoid-dependent modulation of gene expression is critical for normal cell and tissue function in mature as well as developing animals. Despite significant advances in the understanding of retinoid biological activity, important questions remain concerning aspects of retinoid metabohsm, cellular uptake, intracellular trafficking and regulation of gene transcription. The purpose of this review is to present these topics as a compendium of retinoid endocrinology.

This article has been cited by other articles:

				A. Gaal and G Csaba Effect of retinoid (vitamin A or retinoic acid) treatment (hormonal imprinting) through breastmilk on the glucocorticoid receptor and estrogen receptor binding capacity of the adult rat offspring Human and Experimental Toxicology, October 1, 1998; 17(10): 560 - 563. [Abstract] [PDF]

				A. During, A. Nagao, and J. Terao beta -Carotene 15,15'-Dioxygenase Activity and Cellular Retinol-Binding Protein Type II Level Are Enhanced by Dietary Unsaturated Triacylglycerols in Rat Intestines J. Nutr., October 1, 1998; 128(10): 1614 - 1619. [Abstract] [Full Text]