| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
, tumour necrosis factor-β and interferon-
, separately and added together with interleukin-1 β, on the function of cultured human thyroid cells
Interleukin (IL)-1, tumour necrosis factor (TNF)-
and interferon (IFN)-
have been demonstrated in thyroid tissue. We have previously shown that high concentrations of IL-1 inhibit and low concentrations stimulate human thyroid cell function in vitro. In the present study, TNF-, TNF-β and IFN- all inhibited thyroglobulin (Tg) and cAMP production from cultured human thyroid cells. When TNF- was added simultaneously with IL-1 β, the highest concentration of TNF- (106 U/l) enhanced the inhibition of Tg and cAMP induced by IL-1β (1–105 U/1). TNF-β had no influence on IL-1β-induced inhibition. IFN- (104 U/1) added together with IL-1β in lower concentrations (1—102 U/l) stimulated cAMP production, while at high concentrations of IL-1β (105 U/1), IFN- enhanced the inhibitory influence of IL-1 β on Tg production.
The hormones of the immune system, IL-1, TNF and IFN-, may thus contribute to the decreased thyroid function characteristic of some thyroid inflammatory diseases.
Journal of Endocrinology (1994) 143, 359–365
This article has been cited by other articles:
|
|
 |
|
  A. D. Flouris, G. S. Metsios, A. Z. Jamurtas, and Y. Koutedakis Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E456 - E462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Gerard, M. Boucquey, M.-F. van den Hove, and I. M. Colin Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1{alpha}/IFN-{gamma}, an effect partially mediated by nitric oxide Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E242 - E253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Dohan, A. De la Vieja, V. Paroder, C. Riedel, M. Artani, M. Reed, C. S. Ginter, and N. Carrasco The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance Endocr. Rev., February 1, 2003; 24(1): 48 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De la Vieja, O. Dohan, O. Levy, and N. Carrasco Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology Physiol Rev, July 1, 2000; 80(3): 1083 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ohmori, N. Harii, T. Endo, and T. Onaya Tumor Necrosis Factor-{alpha} Regulation of Thyroid Transcription Factor-1 and Pax-8 in Rat Thyroid FRTL-5 Cells Endocrinology, October 1, 1999; 140(10): 4651 - 4658. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Tornquist, A.-M. Malm, M. Pasternack, R. Kronqvist, S. Bjorklund, R. Tuominen, and J. P. Slotte Tumor Necrosis Factor-alpha , Sphingomyelinase, and Ceramide Inhibit Store-operated Calcium Entry in Thyroid FRTL-5 Cells J. Biol. Chem., April 2, 1999; 274(14): 9370 - 9377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. van der Poll, E. Endert, S. M. Coyle, J. M. Agosti, and S. F. Lowry Neutralization of TNF does not influence endotoxininduced changes in thyroid hormone metabolism in humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R357 - R362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Rasmussen, M. Diamant, M. Blichert-Toft, K. Bendtzen, and U. Feldt-Rasmussen The Effects of Interleukin-1{beta} (IL-1{beta}) on Human Thyrocyte Functions Are Counteracted by the IL-1 Receptor Antagonist Endocrinology, May 1, 1997; 138(5): 2043 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Ajjan, P. F. Watson, and A. P. Weetman Detection of IL-12, IL-13, and IL-15 Messenger Ribonucleic Acid in the Thyroid of Patients with Autoimmune Thyroid Disease J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 666 - 669. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
