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The objective of this study was to determine whether circulating concentrations or prior exposure to oestradiol-17β (OE₂) and progesterone affected their uptake by splanchnic tissues. Catheters were surgically placed in the portal vein, a branch of the hepatic vein, a mesenteric vein and the abdominal aorta of three multiparous ovariectomized Dorset ewes. Blood and plasma flow across the portal-drained viscera (PDV) and the liver, and net uptake of OE₂ and O₂ consumption in these same tissues were determined in ovariectomized ewes (control), during OE₂ infusion into the jugular vein, 7 days after an OE₂ implant had been given, and during OE2 infusion into the jugular vein 7 days after an OE₂ implant. The above treatments were repeated for progesterone. Plasma flows across visceral organs were determined by marker dilution (para-aminohippuric acid), and OE₂ and progesterone concentrations were determined by radioimmunoassay. During the infusion with OE₂, OE₂ arterial concentration (mean ± S.D.) was 346 ± 199 pg/ml, PDV net uptake was 9·7±5·6 µg OE₂/h and hepatic net uptake was 15·5 ± 9·5 µg OE₂/h. Hepatic uptake was 82% of the jugular OE₂ infusion rate. Blood flow and oxygen consumption by hepatic tissue increased when ewes were exposed to an OE₂ implant for 7 days. During the infusion with progesterone, progesterone arterial concentration (mean ± S.D.) was 8·8 ±3·4 ng/ml, PDV net uptake was 220 ± 118 µg progesterone/h and hepatic net uptake was 238 ± 52 µg progesterone/h. Hepatic net uptake was 23% of the progesterone jugular infusion rate.

Journal of Endocrinology (1994) 141, 353–358

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