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Inhibin 
- and βB-subunit mRNA expression, and levels of bioactive and immunoreactive inhibin were studied in rat testes, synchronized for the stage of the cycle of the seminiferous epithelium by treating vitamin A-deficient rats with vitamin A. Measurement of inhibin subunit mRNA expression and inhibin levels was started directly after the start of vitamin A treatment, and continued for 65 days.
Inhibin subunit mRNA expression, and testicular bioactive and immunoreactive inhibin levels increased after the start of vitamin A treatment, reaching maximum values after 9 days, when B spermatogonia and preleptotene spermatocytes had appeared in the stage-synchronized testes. The ratio between βB- and -subunit mRNA expression was high at that time-point, whereas the ratio between bioactive and immunoreactive inhibin remained low. These data suggest a relatively high production of activin at that moment, and this may play a role in the development of B spermatogonia into preleptotene spermatocytes during the initiation of spermatogenesis.
Stage-dependency was demonstrated for inhibin subunit mRNA expression, and for the levels of bioactive and immunoreactive inhibin, in rats with complete spermatogenesis. Inhibin -subunit mRNA expression was relatively high at stages V and XIII of the spermatogenic cycle, whereas βB-subunit mRNA expression was high at stage XIII but not at stage V. This resulted in a high βB/ subunit mRNA ratio at stage XIII. Since it has been shown that expression of the activin receptor is high at stages XIII–I, locally formed activin might play a role in the regulation of meiosis. Bioactive and immunoreactive inhibin were highly correlated during the cycle, with maximum levels at stages XIV–I.
It was concluded that the production of inhibin, and possibly activin, is dependent on the stage of the cycle of the seminiferous epithelium; these growth factors might play a paracrine role in the differentiation of spermatogenic cells.
Journal of Endocrinology (1994) 141, 131–141
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