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The discovery of growth hormone-binding proteins (GHBP) in the mid-1980s has provided considerable impetus to the elucidation of growth hormone (GH) action. The unexpected finding of a circulating GH 'receptor' – the high-affinity GHBP – in serum has facilitated assessment of GH receptor status in humans through a simple venipuncture, whereas previously GH receptors could only be reliably quantified in liver. Although it remains to be rigorously proven that the GHBP level in serum reflects tissue GH receptor concentrations, there is mounting evidence that this is indeed the case. Comprehensive reviews of this field have recently appeared (Baumann 1993, Mercado & Baumann 1993); the present commentary will therefore give essential background and primarily focus on conceptual issues and areas where knowledge or understanding is incomplete. The reader is referred to these review articles for full bibliographic citation. For the sake of clarity and the purposes of this article, the term

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