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In the sheep, goat and pig, radiolabelled parathyroid hormone related protein (PTHRP) and immunoreactive PTHRP(1–34) and (1–86) were rapidly cleared from the circulation. Metabolic clearance rates (MCR) were in the range of 1·25–7·5 ml/min per kg and were slightly slower than that of intact PTH in man (10 ml/min per kg); while the mean MCR of labelled PTHRP(1–86) in fetal sheep and goats was significantly faster than that in their respective mothers (14·4 vs 4·0 ml/min per kg respectively). This may reflect increased metabolism of PTHRP by fetal tissues, e.g. the placenta. Similar rates of clearance of radiolabelled PTHRP(1–141), (1–86) and (1–34) suggest that clearance involves the amino terminus of the molecule.

Journal of Endocrinology (1993) 138, 459–465

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