JOE Society for Endocrinology Archive
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Endocrinology (1992) 132, 331-337       DOI: 10.1677/joe.0.1320331
© 1992 Society for Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (76)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jessop, D. S.
Right arrow Articles by Lightman, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jessop, D. S.
Right arrow Articles by Lightman, S. L.

Substance P: multifunctional peptide in the hypothalamo-pituitary system?

 D. S. Jessop, H. S. Chowdrey, P. J. Larsen and S. L. Lightman

Introduction: Substance P (SP) is a bit like the fifth man in British espionage – around for a long time but never named. Because this peptide was originally discovered during the search for acetylcholine (Von Euler & Gaddum, 1931) and, much later, isolated and sequenced by a group more interested in corticotrophin-releasing factor (Chang, Leeman & Niall, 1971), one could be forgiven for thinking that it was decreed to remain anonymous as punishment for obstructing more urgent research. The truth is, however, that so many actions have been ascribed to SP that no sufficiently dominant function has arisen to justify the appellation of a descriptive noun. The properties of vasodilation and smooth muscle contraction are well known (Iversen, Watson, Sandberg et al. 1985), and SP is also strongly implicated in the process of nociception (Iversen, 1982). In addition to these classically described functions, closer attention has been paid more recently




This article has been cited by other articles:


Home page
 Exp PhysiolHome page
M. D. Womack and R. Barrett-Jolley
Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats
Exp Physiol, July 1, 2007; 92(4): 671 - 676.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
B. H. Duvilanski, P. O. Castrillon, P. Cano, M. O. Velardez, and A. I. Esquifino
Changes in Substance P Content at the Hypothalamic-Pituitary Axis during the Wallerian Degeneration of Peripheral Sympathetic Neurons after Superior Cervical Ganglionectomy in Male Rats: Effect of Hyperprolactinemia
Experimental Biology and Medicine, June 1, 2001; 226(6): 612 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy
Prolactin: Structure, Function, and Regulation of Secretion
Physiol Rev, October 1, 2000; 80(4): 1523 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
S. A. Sower, K. Suzuki, and K. L. Reed
Perspective: Research Activity of Enteropancreatic and Brain/Central Nervous System Hormones Across Invertebrates and Vertebrates
Integr. Comp. Biol., April 1, 2000; 40(2): 165 - 178.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
G. P. Chrousos
The Hypothalamic-Pituitary-Adrenal Axis and Immune-Mediated Inflammation
N. Engl. J. Med., May 18, 1995; 332(20): 1351 - 1363.
[Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the Society for Endocrinology.