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The propensity of ionic lithium to interfere with the coupling of receptors to guanine nucleotide binding proteins (G-proteins) has only recently been investigated using rat cortical membranes. In the present study we have used intact isolated osteoclasts to investigate lithium-induced uncoupling of the receptor-mediated actions of calcitonin. All actions of calcitonin on the osteoclast were abolished by ionic lithium. We believe that the cation prevents signal transduction by inhibiting G protein-receptor interaction, the first step in intracellular signalling.

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				E. D. Risby, J. K. Hsiao, H. K. Manji, J. Bitran, F. Moses, D. F. Zhou, and W. Z. Potter The Mechanisms of Action of Lithium: II. Effects on Adenylate Cyclase Activity and {beta}-Adrenergic Receptor Binding in Normal Subjects Arch Gen Psychiatry, June 1, 1991; 48(6): 513 - 524. [Abstract] [PDF]