HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miki, N. Articles by Shizumen, K. Search for Related Content PubMed PubMed Citation Articles by Miki, N. Articles by Shizumen, K.

Secretion of GH occurs in episodic bursts under the dual control of two hypothalamic peptides, GH-releasing factor (GRF) and GH-inhibiting factor (somatostatin, SRIF). Recent studies in rats suggest that episodic GH secretion is generated by the periodic release of GRF, which is associated with the simultaneous withdrawal of SRIF secretion. To test the possibility that GRF discharge is functionally coupled with the withdrawal of SRIF, we investigated whether acute withdrawal of SRIF can induce GRF release by the rat hypothalamus using highly specific antisera against SRIF and rat GRF. In conscious unrestrained rats, i.v. administration of SRIF antiserum at the period of the GH trough induced a rapid onset of the GH secretory surge with a peak value of 309 ± 67 µg/l (mean ± S.E.M.) 30 min after injection. Pretreatment with antiserum to rat GRF resulted in a 83% suppression of the GH surge induced by SRIF antiserum without affecting the trough GH values. GRF antiserum also significantly inhibited the spontaneous GH surge. In urethane-anaesthetized rats, as in conscious rats, an acute phasic GH release was caused by SRIF antiserum despite the interference of anaesthesia with spontaneous GH secretion. A further surge-like GH secretion was not restored during the next several hours, however, with the GH secretory profile being characterized by a tonic increase in the baseline levels of GH. In the anaesthetized rat antiserum to rat GRF, having no effect on basal GH levels, similarly inhibited by 66% the acute GH surge induced by SRIF antiserum and decreased by about 30% the later sustained rise in GH.

These results indicate that an acute rather than a chronic withdrawal of SRIF can trigger the phasic discharge of GRF by the hypothalamus, and raise the possibility that SRIF, originally isolated as a hypothalamic hypophysiotrophic GH-inhibiting factor, also acts as a GRF-inhibiting factor within the hypothalamus. We suggest that the episodic GH secretion may be initiated by an acute disinhibition of GRF secretion caused by the sudden withdrawal of SRIF.

J. Endocr. (1988) 117, 245–252

This article has been cited by other articles:

				J. D. Veldhuis, S. A. Hudson, J. N. Bailey, and D. Erickson Regulation of basal, pulsatile, and entropic (patterned) modes of GH secretion in a putatively low-somatostatin milieu in women Am J Physiol Endocrinol Metab, August 1, 2009; 297(2): E483 - E489. [Abstract] [Full Text] [PDF]

				L. S. Farhy, C. Y. Bowers, and J. D. Veldhuis Model-projected mechanistic bases for sex differences in growth hormone regulation in humans Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1577 - R1593. [Abstract] [Full Text] [PDF]

				J. D. Veldhuis, L. Farhy, A. L. Weltman, J. Kuipers, J. Weltman, and L. Wideman Gender Modulates Sequential Suppression and Recovery of Pulsatile Growth Hormone Secretion by Physiological Feedback Signals in Young Adults J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2874 - 2881. [Abstract] [Full Text] [PDF]

				L. S. Farhy and J. D. Veldhuis Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1030 - R1042. [Abstract] [Full Text] [PDF]

				J. D. Veldhuis, S. M. Anderson, J. T. Patrie, and C. Y. Bowers Estradiol Supplementation in Postmenopausal Women Doubles Rebound-Like Release of Growth Hormone (GH) Triggered by Sequential Infusion and Withdrawal of Somatostatin: Evidence that Estrogen Facilitates Endogenous GH-Releasing Hormone Drive J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 121 - 127. [Abstract] [Full Text] [PDF]

				H. E. Pruett, D. L. Thompson Jr., J. A. Cartmill, C. C. Williams, and L. R. Gentry Thyrotropin releasing hormone interactions with growth hormone secretion in horses J Anim Sci, September 1, 2003; 81(9): 2343 - 2351. [Abstract] [Full Text] [PDF]

				E. V. Dimaraki, C. A. Jaffe, C. Y. Bowers, P. Marbach, and A. L. Barkan Pulsatile and nocturnal growth hormone secretions in men do not require periodic declines of somatostatin Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E163 - E170. [Abstract] [Full Text] [PDF]

				E. Richmond, A. D. Rogol, D. Basdemir, O. L. Veldhuis, W. Clarke, C. Y. Bowers, and J. D. Veldhuis Accelerated Escape from GH Autonegative Feedback in Midpuberty in Males: Evidence for Time-Delimited GH-Induced Somatostatinergic Outflow in Adolescent Boys J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3837 - 3844. [Abstract] [Full Text] [PDF]

				L. S. Farhy, M. Straume, M. L. Johnson, B. Kovatchev, and J. D. Veldhuis A construct of interactive feedback control of the GH axis in the male Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R38 - R51. [Abstract] [Full Text] [PDF]

				E. V. Dimaraki, C. A. Jaffe, R. Demott-Friberg, M. Russell-Aulet, C. Y. Bowers, P. Marbach, and A. L. Barkan Generation of growth hormone pulsatility in women: evidence against somatostatin withdrawal as pulse initiator Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E489 - E495. [Abstract] [Full Text] [PDF]

				C. Lanneau, M. T. Bluet-Pajot, P. Zizzari, Z. Csaba, P. Dournaud, L. Helboe, D. Hoyer, E. Pellegrini, G. S. Tannenbaum, J. Epelbaum, et al. Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: An in Vitro and in Vivo Antisense Study Endocrinology, March 1, 2000; 141(3): 967 - 979. [Abstract] [Full Text] [PDF]

				L. Beranek, I. Hajdu, J. Gardi, P. Taishi, F. Obal Jr., and J. M. Krueger Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1999; 277(5): R1297 - R1304. [Abstract] [Full Text] [PDF]

				A. Giustina and J. D. Veldhuis Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human Endocr. Rev., December 1, 1998; 19(6): 717 - 797. [Abstract] [Full Text]

				L. Beranek, F. Obal Jr., P. Taishi, B. Bodosi, F. Laczi, and J. M. Krueger Changes in rat sleep after single and repeated injections of the long-acting somatostatin analog octreotide Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1484 - R1491. [Abstract] [Full Text] [PDF]