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The direct effects of changes in extracellular hydrogen ion (H⁺) concentration on aldosterone secretion under basal, angiotensin II- and potassium-stimulated conditions were studied in isolated, perfused canine adrenal glands. Changes in extracellular H⁺ concentration were induced by altering either the partial pressure of CO₂ (pCO₂) or the HCO₃^– concentration of the perfusate. Acid-base disturbances had a more pronounced effect on aldosterone secretion under stimulated than under basal conditions. Increasing H⁺ concentration enhanced angiotensin II- and potassium-stimulated aldosterone secretion, whereas decreasing H⁺ concentration markedly inhibited the secretory response to these stimuli. Because changes in H⁺ concentration, whether produced by varying extracellular pCO₂ or extracellular HCO₃^– concentration, had similar effects on angiotensin II-stimulated aldosterone secretion, the data suggest that H⁺ concentration per se is the important determinant of the aldosterone secretory rate. Interestingly, during the immediate recovery period from pCO₂-induced alkalosis under both angiotensin II- and potassium-stimulated conditions, aldosterone secretion always returned to a value significantly higher than that obtained just before alkalosis. The results of this study demonstrate that changes in extracellular H⁺ concentration influence the rate of aldosterone secretion, possibly via changes in intracellular pH, by a direct action on the canine adrenal gland. Therefore, when evaluating the control of aldosterone secretion, the acid-base status of the whole animal or of in-vitro adrenal tissue must be considered.

J. Endocr. (1986) 110, 293–301