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Peripheral serum concentrations of LH, FSH and prolactin were determined by radioimmunoassay on different days after birth in the female rabbit. Serum cholesterol concentrations were also analysed by a colorimetric method. Concentrations of serum LH and FSH showed two distinct peaks occurring on day 9 (LH, 4·05 ± 0·76 (mean ± S.E.M.) µg/l; FSH, 3·62 ± 0·67 µg/l) and either day 35 (LH, 5·90 ± 1·20 µg/l) or day 40 (FSH, 9·01 ± 1·43 µg/l). Concentrations of LH and FSH were in the adult range (LH, < 1 µg/l; FSH, < 0·6 µg/l) by day 100. Serum prolactin showed a progressive increase from day 1 (1·04 ± 0·07 µg/l) to day 100 ( 17·30 ± 2·50 µg/l) with a peak on day 40. Total serum cholesterol in another series of rabbits was high from days 1 to 22 (7·53 ± 0·64 mmol/l) and then decreased to 1·94–3·36 mmol/l by day 106. These data indicate that the two major developmental peaks in gonadotrophins may be related to ovarian function.

J. Endocr. (1986) 109, 287–290