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Serum GH concentrations in steers were examined during extended treatment with synthetic GH-releasing factor(1–44)NH₂ (GRF). The results indicate that GRF given as frequent microinjections stimulate and sustain raised serum GH concentrations for at least 5 days in steers. The GH secretory pattern remained episodic and was characterized by a significant increase in the amplitude of the GH pulses without a change in the number of GH pulses per day.

In the first of two experiments, young Holstein steers received 0, 0·05, 0·5 or 5·0 mg GRF during a 24-h period as microinjections every 3·75 min. The 5·0 mg GRF/24 h dose significantly increased baseline GH, amplitude of GH pulses and area under the GH curve compared with the other treatments. The number of GH pulses/24 h was similar for all doses of GRF. In a second experiment with Holstein steers, administration of 3·6 mg GRF/day for 5 days increased serum GH concentrations throughout the duration of the treatment without altering the temporal GH secretory pattern. The GH response to GRF did not diminish from days 1 to 5 of treatment suggesting that there was no pituitary desensitization.

J. Endocr. (1985) 104, 433–439