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Angiotensin II and I significantly raised potassium and lowered sodium and chloride ion concentrations in arterial plasma, with peak changes occurring in the first 2 min of a 6-min infusion period. The octapeptide increased the arterial K⁺ level in a dose-dependent manner, but the response showed tachyphylaxis when multiple infusions of 6-min duration were administered after a recovery interval of only 5 min. Raising the arterial blood pressure by 20–33 mmHg with adrenaline and noradrenaline failed to account for the increase in arterial plasma K⁺ concentration produced by the two peptides. These findings, in particular the rise in K⁺ concentration, are discussed in relation to possible mechanisms by which angiotensin II affects arteriolar tone.

J. Endocr. (1985) 104, 143–148