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Institute of Histology and Embryology, University of Geneva Medical School, Geneva, Switzerland

The lecture was given during the 2nd Joint Meeting of British Endocrine Societies at the University of York on 7 April 1983

In the present paper, the insulin cell (B-cell) will be considered from three points of view: intracellular, intercellular and transcellular. 'Intracellular' covers the synthesis/secretion of insulin by the B-cell; 'intercellular' the relationship of B-cells with other endocrine cells within the islet of Langerhans and 'transcellular' the gap junctional communication between islet cells. This paper updates a previous review on the same subject (Orci, 1982) and presents several new developments in the area.

INTRACELLULAR: Since the beginning of electron microscopy in the study of the insulin cell (for review see Lacy, 1967), the difficulty in relating morphological images of insulin secretory granule formation (Plate 1) (Orci, Stauffacher, et al. 1969; Orci, 1974) to the now