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THE function of the placentae in the mouse can be studied by eliminating the other products of gestation on or about the 12th day of pregnancy. It has been shown that in the presence of the retained placentae the remaining week of 'pregnancy' approximates very closely to the normal, in spite of the absence of the growing foetuses. Thus, the placentae are delivered at normal full term, and delivery is accompanied by a loss of weight greatly in excess of that of the placentae and is followed by oestrus. In the interval between foetal destruction and delivery of the placentae the weight added during the first part of pregnancy is maintained and oestrus is suppressed [Newton, 1935; Brooksby and Newton, 1938]. Mammary development and ligamentous transformation of the symphysis pubis [Gardner, 1936] proceed normally, and 19 days after impregnation mammary glands and symphysis pubis are indistinguishable from those at the