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DURING the past few years it has become clear that anterior pituitary glands from different species of animal contain different proportions of physiologically active substances. Loeb and Friedman [1933], in comparing the anterior pituitary glands of various species, distinguished two groups according to their contents of gonadotrophic and thyrotrophic hormones. In one class, in which they placed ox, sheep, and pig, the gland possessed high thyrotrophic activity and high gonadotrophic activity of the type considered to be due to the 'luteinizing hormone' of the gonadotrophic complex. In the second class, in which they placed the cat, rat, guineapig, and rabbit, the pituitary gland contained little thyrotrophic hormone but a larger proportion of the follicle-stimulating constituent of the gonadotrophic complex. In this second class it is possible also to place the horse and adult man [Rowlands, 1936; Henderson and Rowlands, 1938; Cope, 1938]. An association between the thyrotrophic and the luteinizing